Oncology Certified Nurse (OCN) Nursing Practice Test 2025 - Free OCN Practice Questions and Study Guide.

High doses of cyclophosphamide can lead to damaged cardiac endothelium, which is a significant concern in oncology nursing. Cyclophosphamide is an alkylating agent commonly used in chemotherapy, and its cardiotoxic effects are primarily linked to the dose administered and the cumulative exposure over time.

When cyclophosphamide is introduced into the body, it can generate reactive metabolites that lead to oxidative stress. This oxidative stress can damage the endothelial cells that line the blood vessels of the heart, disrupting normal function and possibly leading to conditions such as heart failure or pulmonary hypertension. Endothelial dysfunction can also affect vascular relaxation and contraction, further contributing to cardiovascular complications.

Understanding this side effect is crucial for oncology nurses, as they play a vital role in monitoring patients for signs of cardiovascular compromise and providing education on potential symptoms that may arise following treatment with cyclophosphamide. This knowledge emphasizes the importance of regular cardiovascular assessments in patients receiving high-dose chemotherapy regimens.