Oncology Certified Nurse (OCN) Nursing Practice Test

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Prepare for the Oncology Certified Nurse Test. Enhance your skills with flashcards and multiple-choice questions, each backed by hints and explanations. Get ready for your certification!

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Which chromosome is most commonly abnormal in renal cell carcinoma?

Chromosome 5p
Chromosome 3p
Chromosome 20q
Chromosome 17

The correct answer is: Chromosome 3p

Renal cell carcinoma (RCC) is often associated with specific genetic changes, and one of the most notable is the alteration of chromosome 3. In particular, losses of heterozygosity at the 3p position are frequently observed in RCC. This region of the chromosome harbors the VHL (von Hippel-Lindau) gene, which is a tumor suppressor gene that plays a crucial role in regulating cell growth and apoptosis. When this gene is mutated or deleted, it can lead to uncontrolled cell proliferation and the development of renal cell carcinoma. The association of chromosome 3p anomalies with renal cell carcinoma is significant in both the pathogenesis and the potential development of targeted therapeutic strategies. Understanding these genetic abnormalities assists healthcare providers in offering more informed prognostic information and treatment options for patients diagnosed with RCC. The presence of other abnormal chromosomes, while relevant to various cancers, does not have the same established correlation with RCC as chromosome 3p.